A significant amount of effort is necessary to obtain protein stability and functional data from animal models. Protein stability may be lost in formulations meant to last for 2-3 months. One potential advantage of the PK-Eye™ is the ease to evaluate protein properties such as stability and functionality.

 

Animals also quickly develop anti-drug antibodies (ADAs), which is an intractable problem that negatively impacts the preclinical development of long lasting dosage forms or devices for ocular use.